Synaptic remodeling in experimental models of Huntington’s disease
Huntington’s disease (HD) is most known for the severe motor disorders it causes. Its earliest symptoms, however – often manifesting years before severe motor symptoms develop – are cognitive deficits and neuropsychiatric disorders, which gradually deteriorate into dementia and severe behavioral problems. These early aspects of the disease have been attributed, in part, to synaptic dysfunction and loss. This project aims to examine and compare various aspects of synaptic biology and function in experimental models of this disease using proteomics, fluorescent reporters, long-term imaging and chronic electrophysiological recordings.