Laurie Cohen

Synaptic protein catabolism

Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis and trafficking, much less is known on the manners by which synaptic proteins are degraded. This project seeks to examine the roles of canonical catabolic pathways in the degradation of  synaptic proteins using proteomics,  bioinformatics, long-term imaging techniques, chronic recordings, pharmacological / molecular perturbations and  immunocytochemistry.